FEATURED EDITORIAL
The laboratory information management system (LIMS) landscape in 2024 is a dynamic one, driven by accelerating advancements in technology and evolving industry needs. This article shares the four key trends.
- FDA’s Updated Guidance On Human Genome Editing: New Implications & Remaining Questions
- AI's Role In Advancing Rare Disease Research
- FDA’s CBER Issues Final Guidance For CAR T Cell Products
- PROTACs And Molecular Glues: Rethinking What Is Possible
- 2024 And Beyond: The State Of Alzheimer's Disease Research And Drug Development
- Indo-U.S. Collaboration Can Accelerate Drug Discovery — Here’s How
- FDA Draft Guidance On “Rare Diseases: Considerations For The Development Of Drugs And Biological Products”
FEATURED APPLICATION CONTENT
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Explore key process operations, some of the challenges in manufacturing high-concentration biologics, and factors to consider for process optimization.
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Here, we review how an advanced in vitro model closely aligned with the human duodenum was utilized to evaluate the toxicity of indomethacin, a known gastrointestinal toxicant.
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Learn about a novel preclinical model and how it enables the study of cytokine-mediated barrier inflammation mechanisms as well as the efficacy of anti-inflammatory therapeutics.
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An evaluation of 150 drug candidates causing adverse events in humans revealed testing in rats and dogs predicted only 71% of toxicities in humans. Discover a solution to this translational challenge.
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Here, we analyze the throughput performance of sterilizing grade filters across moderate-to-high concentrations of mAbs and immunoglobulins and demonstrate how filter selection can impact your process.
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Here, we demonstrate a scalable workflow for the isolation of exosomes that combines tangential flow filtration for the concentration of exosomes followed by gentle size exclusion chromatography.
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Evaluate the performance of a single-use two-step plasmid purification process, and see how it compares to the existing three-step purification method.
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Explore five key areas in oligonucleotide chemistry where improvements will have a huge influence on your synthesis quality.
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There is a growing demand for closed and automated lentiviral transduction steps in CAR T cell therapy workflows. Learn about a potential solution to address this unmet need.
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Combining high productivity chromatography methods and SU affinity membranes deliver a viable alternative to the current packed bed Protein A capture techniques for intensified purification of mAbs up to commercial production scale.
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Explore a stepwise approach for integrating process intensification principles into an existing process to increase productivity, reduce costs, and improve process sustainability.
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We describe how intensifying two chromatography polishing steps by developing unit operations using Sartobind® Q and CMM HyperCel saves buffer volumes and accelerates the downstream process.
FEATURED NEWS HEADLINES
- U.S. Food And Drug Administration (FDA) Has Accepted The New Drug Application (NDA) For Ensartinib
- Poseida Therapeutics Announces FDA Orphan Drug Designation Granted To P-BCMA-ALLO1 For The Treatment Of Multiple Myeloma
- Allumiqs And Prolytix Form Strategic Partnership To Accelerate Drug Discovery And Development
- UCT’s H3D Spearheads Africa’s Drug Discovery Accelerator Programme
- UCF Researcher Pioneers Chiral Molecule Sensing Method To Enhance Drug Development
- Automated High-Throughput Sorting Of Living Cells Using Laser Light And AI
- AION Labs Launches CombinAble.AI To Reduce Time And Cost Of Targeted Antibody Design, Advancing Optimization Of Drug Development
- GV20 Therapeutics Joins NVIDIA Inception To Develop AI Models For Drug And Target Discovery
- AbCellera To Collaborate With Biogen To Discover Therapeutic Antibodies For Neurological Conditions
- Ubiquigent Enters Agreement With Astellas Subsidiary, Nanna Therapeutics
ARCHIVED NEWSLETTER
- 03.19.24 -- Understanding Undruggable Targets: Challenges And Progress
- 03.18.24 -- Regulatory & GMP Manufacturing Insights Into mRNA-LNP Drug Products
- 03.13.24 -- Achieving Efficient Process Development And Validation
- 03.12.24 -- The Benefits Of Using GenAI In Drug Discovery And Preclinical Development
- 03.05.24 -- Finding New Treatments In Old Therapies