DRUG DISCOVERY FEATURED ARTICLES & APPLICATIONS

  • Imaging And Analysis Of A High Density Cell Migration Assay
    Imaging And Analysis Of A High Density Cell Migration Assay

    Complex biological or environmental signaling events can lead to cell migration, the movement of cells from one location to another. The migration of cells commonly occurs during both normal biological processes such as the development of an organism or marking pathological events such as cancer metastasis. Automated processes in higher density formats improve throughput greatly increasing the usefulness of performing migration assays at a larger scale. This study evaluated the use of a high density cell exclusion assay in 384- well format for investigation of cell migration using a cell line stably expressing green fluorescent protein (GFP).

  • Getting The Most Out Of Your Viral Clearance Study

    By John Zehmer, PhD, Senior Scientist and Study Director at BioReliance

    Conducting a viral clearance study is an important step on the road toward getting your biomolecule into the clinic and on its way to becoming a drug. However, since most companies do not have the systems in place to support a regulated virological study of this kind, this will likely mean engaging a contract research organization (CRO) as a partner. The keys to meeting your goals are solid planning and good communication between your group and your CRO partner. This article provides a high-level review of these processes and will aid in planning for a successful study.

  • Tools for the Design of Vaccines to Help Reduce Clinical Failure

    If you are involved in the pharma industry, then you are interested in saving lives. In the area of preventative medicine, therapeutic vaccines have proven to have a tremendous impact on the ability to save millions of lives. Similar to pharmaceuticals, vaccine development can take over 10 years and less than 10 percent of candidates reach commercialization. Reducing the cost of failure and increasing the chances of clinical success for vaccines is beneficial to both the pharma industry and those being treated for or protected from disease.

  • Patheon Surfs Outsourcing Waves And Scoops Up Gallus Along The Way

    Jim Mullen, CEO of Patheon parent company DPx Holdings B.V., is at it again.

    On the heels of my three-part series with Mullen on the details behind the springtime merger of his company and the pharmaceutical products division of Royal DSM, he has made his next move.

    This time it is a strategic entrée into the U.S.-based market for biologics services via an acquisition of privately held Gallus BioPharmaceuticals. With Gallus, Patheon adds new capabilities at well-established sites with name-brand clientele, in St. Louis, Mo. and Princeton, N.J., to its global locations in Groningen, the Netherlands and Brisbane, Australia.

  • Systematic Method Development Of UPC2 Conditions Using Opioid Drugs

    This application note uses a panel of natural and synthetic opioid drugs to demonstrate the use of a systematic screening strategy for UPC2 method development. By Jonathan P. Danaceau, Kenneth J. Fountain, and Erin E. Chambers, Waters Corporation

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FEATURED PRODUCTS AND SERVICES

Marketing Intelligence and Strategic Thinking

Marketing Intelligence and Strategic Thinking

Nice Insight offers products and services focused on a variety of marketing intelligence needs. Whether you need a macro understanding of the contract manufacturing industry, or a micro understanding of particular providers and capabilities, Nice Insight can help with your market research needs.

Custom Critical SecureComm™: Cargo Security

Custom Critical SecureComm™: Cargo Security

For the utmost in secure shipping, our 24-hour command center, FedEx Custom Critical SecureComm, can provide additional layers of security and oversight for your medical cargo.

Mustang™ Ion Exchange Modules

These Modules provide high performance chromatography at low pressure.
Pilot And Production Scale Freeze Dryers

Pilot And Production Scale Freeze Dryers

Millrock's production freeze dryers have achieved the recognition of being the highest performing machines in the industry. Typical shelf freezing and vapor collecting capacities are unmatched. Coupled with this is our easy to use intuitive control system, the Opti-Dry. Our units are fully validatable and built to cGMP guidelines.
The Rotary Micro Riffler

The Rotary Micro Riffler

The Rotary Micro Riffler automatically divides larger samples into eight smaller representative samples for analysis...
Vibrating Mixer

Vibrating Mixer

The Vibrating Mixer consists of an electromagnetic drive and a stirrer shaft which agitates by vertical reciprocating motion...
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January 8, 2015
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Pediatric Clinical Trials: Special Considerations and Requirements

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January 8, 2015
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Pediatric Clinical Trials: Special Considerations and Requirements

January 12, 2015
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Root Cause Analysis for GCP – A Risk Action Plan Guide

January 16, 2015
1pm-3pm EST, Online Training

Compliance & Validation Requirements for Serialization - Keys to Success

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